Why is a trial of antidepressant treatment, followed by reassessment of cognition, often both a diagnostically useful step and an appropriate clinical intervention in a suspected case?
A treatment trial is useful precisely because depressive pseudodementia's cognitive impairment is secondary to, and improves with treatment of, the underlying depressive illness — a course of recovery a genuine, progressive dementia would not be expected to follow. This makes the treatment trial itself a meaningful diagnostic test, not simply routine care.
References
- Casey, P. & Kelly, B. (2019). Fish's Clinical Psychopathology, 4th ed. Ch. 5, 'Disorders of Memory'.